The Scuola Grande di San Rocco in Venice began as a lay confraternity founded in 1478, dedicated to Saint Roch, the plague saint, and it later became one of the richest and most prestigious religious brotherhoods in the city. Often referred to as “Tintoretto’s Sistine Chapel” due to the amazing work inside.
 
The Scuola was founded by Venetian laymen in 1478 as a charitable and devotional society focused on aid, worship, and care for the sick and poor. Its rise accelerated after it obtained a relic of San Rocco in 1485, which greatly increased its popularity and wealth. The main building was developed in the 16th century, with work extending into the mid-1500s, and the final architectural phase was completed by Giangiacomo dei Grigi.
 
The real transformation came in 1564, when Tintoretto was commissioned to decorate the Scuola, eventually creating one of the greatest pictorial programs in Venice. 
 
Interesting facts...
It is said that Tintoretto secured the commission by placing a finished painting in the intended location before the competition, effectively forcing the confraternity to accept him. A clever move.