The present site is the third used by the parish for its church.
 
 In 1810–11  the third site was secured to build a chapel-of-ease on the south side of the new road near Nottingham Place. facing Regent's Park. Plans were drawn up by Chambers's pupil Thomas Hardwick and the foundation stone was laid on 5 July 1813. When construction was almost complete, it was decided that this new building should serve as the parish church, and so alterations were made to the design. On the north front, towards the new road, a Corinthian portico with eight columns (six columns wide, and two deep at the sides), based on that of the Pantheon in Rome, replaced the intended four-column Ionic portico surmounted by a group of figures. A steeple was built, instead of a planned cupola. No changes were made to the design of the interior, but plans to build houses on part of the site were abandoned
 
A local resident was Charles Dickens (1812–1870), in Devonshire Terrace, whose son was baptised in this church (a ceremony fictionalised in Dombey and Son). Robert Browning and Elizabeth Barrett were married in this phase of the church in 1846 (their marriage certificate is preserved in the church archives). The church was also used in location filming for the 1957 film recounting their story, The Barretts of Wimpole Street.